What is peripheral neuropathy?
Peripheral neuropathy is damage to the nerves outside the brain and spinal cord — most often in the feet, legs, and hands. It shows up as burning, numbness, tingling, sharp pain, balance problems, and weakness. In Wilmington, the most common driver is diabetes: chronically elevated insulin and blood sugar starve nerve cells of usable energy, and the damage slowly accumulates.
Why medication alone usually isn't enough
Gabapentin, pregabalin, duloxetine, and topical agents can dull the pain signal, but they don't repair the underlying nerve. As soon as the medication wears off — or the dose stops being effective — the symptoms return, and the nerve damage continues to progress in the background.
How PIR therapy targets the root cause
Physiologic Insulin Resensitization delivers insulin in physiologic pulses through an IV infusion, mimicking the way a healthy pancreas releases it. Over a course of treatments this re-trains cells to respond to insulin again, restoring the cellular metabolism nerves depend on. With energy and glucose moving correctly into the nerve cell, the body can begin to repair the damage rather than just quiet the symptoms.
Most patients undergo PIR 2–3 times per week for 8–12 weeks, alongside complementary therapies — red light, vibration, shockwave, and Class IV laser — that further support nerve regeneration and circulation.
What patients report
Across our Wilmington practice, the majority of patients completing the program report meaningful reductions in pain and numbness, improved balance, and the ability to reduce or eliminate neuropathy medications under their physician's supervision. Many regain sensation they hadn't felt in years.
Is PIR right for you?
PIR is most effective for patients whose neuropathy is driven by insulin resistance, prediabetes, or Type 2 diabetes — but we also see results in idiopathic and chemotherapy-related cases. The best next step is a consultation: we'll review your history, run baseline labs, and tell you honestly whether you're a candidate.